학력 및 경력사항

• 이화여자대학교 의학박사
• 이화여자대학교 의학석사
• 이화여자대학교 의과대학 졸업

• 2020-현재  | 이화여자대학교 의무부총장 겸 의료원장
• 2015-2018  | 이대목동병원 병원장
• 2010-2011  | 이화의료원 기획조정실장
• 2005-2009  | 이대목동병원 교육연구부장
• 2004-2005  | 이대목동병원 진료협력센터장
• 2001-2003  | 이화여자대학교 의과대학 임상교무부장
• 1998  | UCLA Umbilical cord blood bank visiting doctor
• 1996-현재  | 이화여자대학교 의과대학 소아과학교실 조교수, 부교수, 정교수
• 1996  | 이화여자대학교 부속병원 소아과 전임의사
• 1995-1996  | 서울대학교 어린이병원 소아과 혈액종양 전임의
• 1994-1995  | 이화여자대학교 부속병원 소아과 전임의사
• 1985-1988  | 이화여자대학교 부속병원 소아과 전공의

• 2025 | 제1회 테디스 어워즈 2025(Teddy's award 2025) 희망과 감동상
• 2025 | 제75차 소아청소년과학회 춘계학술대회 학농상
• 2024 | 제28회 대한혈액학회 학술상
• 2024 | 제1회 한국의학바이오기자협회 환자소통 올해의 병원경영인상
• 2023 | 제3회 서울시병원회 동아병원경영대상
• 2013 | 제9회 대한소아혈액종양학회 학술공로상
• 2003 | 제1회 대한면역학회 한올학술상

• 2017  | 대한소아혈액종양학회 이사장
• 2013-2015  | 대한조혈모세포이식학회 학술이사
• 2013-2014  | SIOP2014 국제학회 학술위원장
• 2011-2013  | 대한소아혈액종양학회 학술이사
• 2009-2011  | 대한혈액학회 재무이사
• 2007-2010  | 대한의학회 고시전문위원
• 2007-2009  | 대한혈액학회 학술이사
• 2005-2009  | 한국호스피스완화의료학회 간행이사
• 2001-2015  | 한국백혈병소아암협회 이사
• 2000-2011  | 대한소아혈액종양학회 간행이사
• 1997-1999  | 한국의학교육학회 총무이사

•  Conditioned medium from human tonsilderived mesenchymal stem cells inhibits glucocorticoid-induced adipocyte differentiation.  PLoS ONE. 2022, v.17 no.6-6월, e0266857. 
•  Mesenchymal Stem Cell-Derived Exosomes Attenuate TLR7-Mediated Mast Cell Activation.  Tissue Engineering and Regenerative Medicine. 2022, v.19 no.1, 117-129. 
•  Procollagen C-Endopeptidase Enhancer 2 Secreted by Tonsil-Derived Mesenchymal Stem Cells Increases the Oxidative Burst of Promyelocytic HL-60 Cells.  BIOLOGY-BASEL. 2022, v.11 no.2, 255. 
•  Promotion of Platelet Production by Co-Transplantation of Mesenchymal Stem Cells in Bone Marrow Transplantation.  Tissue Engineering and Regenerative Medicine. 2022, v.19 no.1, 131-139. 
•  Mesenchymal Stem Cell-Derived Exosomes Protect Muscle Loss by miR-145-5p Activity Targeting Activin A Receptors.  CELLS. 2021, v.10 no.8, 2169. 
•  Tonsil-derived mesenchymal stem cells enhance allogeneic bone marrow engraftment via collagen IV degradation.  Stem Cell Research and Therapy. 2021, v.12 no.1, 329. 
•  A Novel Method to Differentiate Tonsil-Derived Mesenchymal Stem Cells In Vitro into Estrogen-Secreting Cells.  Tissue Engineering and Regenerative Medicine. 2020, v.18 no.2, 0. 
•  Co-transplantation of tonsil-derived mesenchymal stromal cells in bone marrow transplantation promotes thymus regeneration and T cell diversity following cytotoxic conditioning.  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2020 , 1166-1174. 
•  Conditioned Medium from Human Tonsil-Derived Mesenchymal Stem Cells Enhances Bone Marrow Engraftment via Endothelial Cell Restoration by Pleiotrophin.  CELLS. 2020, v.9 no.1, 221. 
•  Administration of Tonsil-Derived Mesenchymal Stem Cells Improves Glucose Tolerance in High Fat Diet-Induced Diabetic Mice via Insulin-Like Growth Factor-Binding Protein 5-Mediated Endoplasmic Reticulum Stress Modulation.  CELLS. 2019, v.8 no.4, 368. 
•  Concise Review: Application of Tonsil-Derived Mesenchymal Stem Cells in Tissue Regeneration.  STEM CELLS. 2019, v.37 no.10, 1252-1260. 
•  onditioned medium from human tonsilderived mesenchymal stem cells inhibits glucocorticoid-induced adipocyte differentiation.  PLoS ONE. 2022, v.17 no.6-6월, e0266857. 
•  Mesenchymal Stem Cell-Derived Exosomes Attenuate TLR7-Mediated Mast Cell Activation.  Tissue Engineering and Regenerative Medicine. 2022, v.19 no.1, 117-129. 
•  Procollagen C-Endopeptidase Enhancer 2 Secreted by Tonsil-Derived Mesenchymal Stem Cells Increases the Oxidative Burst of Promyelocytic HL-60 Cells.  BIOLOGY-BASEL. 2022, v.11 no.2, 255. 
•  Promotion of Platelet Production by Co-Transplantation of Mesenchymal Stem Cells in Bone Marrow Transplantation.  Tissue Engineering and Regenerative Medicine. 2022, v.19 no.1, 131-139. 
•  Mesenchymal Stem Cell-Derived Exosomes Protect Muscle Loss by miR-145-5p Activity Targeting Activin A Receptors.  CELLS. 2021, v.10 no.8, 2169. 
•  Tonsil-derived mesenchymal stem cells enhance allogeneic bone marrow engraftment via collagen IV degradation.  Stem Cell Research and Therapy. 2021, v.12 no.1, 329. 
•  A Novel Method to Differentiate Tonsil-Derived Mesenchymal Stem Cells In Vitro into Estrogen-Secreting Cells.  Tissue Engineering and Regenerative Medicine. 2020, v.18 no.2, 0. 
•  Co-transplantation of tonsil-derived mesenchymal stromal cells in bone marrow transplantation promotes thymus regeneration and T cell diversity following cytotoxic conditioning.  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2020 , 1166-1174. 
•  Conditioned Medium from Human Tonsil-Derived Mesenchymal Stem Cells Enhances Bone Marrow Engraftment via Endothelial Cell Restoration by Pleiotrophin.  CELLS. 2020, v.9 no.1, 221. 
•  Administration of Tonsil-Derived Mesenchymal Stem Cells Improves Glucose Tolerance in High Fat Diet-Induced Diabetic Mice via Insulin-Like Growth Factor-Binding Protein 5-Mediated Endoplasmic Reticulum Stress Modulation.  CELLS. 2019, v.8 no.4, 368. 
•  Concise Review: Application of Tonsil-Derived Mesenchymal Stem Cells in Tissue Regeneration.  STEM CELLS. 2019, v.37 no.10, 1252-1260. 
•  Conditioned Medium from Tonsil-Derived Mesenchymal Stem Cells Relieves CCl 4 -Induced Liver Fibrosis in Mice.  Tissue Engineering and Regenerative Medicine. 2019, v.16 no.1, 51-58. 
•  Conditioned medium from human palatine tonsil mesenchymal stem cells attenuates acute graft-vs.-host disease in mice.  Molecular Medicine Reports. 2019, v.19 no.1, 609-616. 
•  Identification of WNT16 as a Predictable Biomarker for Accelerated Osteogenic Differentiation of Tonsil-Derived Mesenchymal Stem Cells In Vitro.  STEM CELLS INTERNATIONAL. 2019, v.2019, 8503148. 
•  Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naive CD4 T Lymphocytes in Mice.  Acta Derm Venereol. 2019 May 1;99(6):594-601. 
•  Administration of Tonsil-Derived Mesenchymal Stem Cells Improves Glucose Tolerance in High Fat Diet-Induced Diabetic Mice via Insulin-Like Growth Factor-Binding Protein 5-Mediated Endoplasmic Reticulum Stress Modulation.  Cells. 2019 Apr 23;8(4). 
•  Conditioned medium from human palatine tonsil mesenchymal stem cells attenuates acute graft‑vs.‑host disease in mice..  Mol Med Rep. 2018-11. 
•  Conditioned Medium from Tonsil-Derived Mesenchymal Stem Cells Relieves CCl4-Induced Liver Fibrosis in Mice.  Tissue Eng Regen Med. 2018-10. 
•  Tonsil-derived mesenchymal stem cell-embedded in situ crosslinkable gelatin hydrogel therapy recovers postmenopausal osteoporosis through bone regeneration.  PLoS One. 2018-07. 
•  Tonsil-derived mesenchymal stem cells (T-MSCs) prevent Th17-mediated autoimmune response via regulation of the programmed death-1/programmed death ligand-1 (PD-1/PD-L1) pathway.  J Tissue Eng Regen Med. 2018-02. 
•  RNA sequencing reveals a transcriptomic portrait of human mesenchymal stem cells from bone marrow, adipose tissue, and palatine tonsils.  Sci Rep. 2017-12. 
•  Conditioned medium from tonsil‑derived mesenchymal stem cells promotes adiponectin production.  Mol Med Rep. 2017-11. 
•  Mesenchymal stem cells inhibit RANK-RANKL interactions between osteoclasts and Th17 cells via osteoprotegerin activity.  Oncotarget. 2017-09. 
•  Poly I:C primes the suppressive function of human palatine tonsil-derived MSCs against Th17 differentiation by increasing PD-L1 expression.  Immunobiology. 2017-02. 
•  Mesenchymal stem cells ameliorate B-cell-mediated immune responses and increase IL-10-expressing regulatory B cells in an EBI3-dependent manner.  Cell Mol Immunol. 2017-01. 
•  Conditioned media from human palatine tonsil mesenchymal stem cells regulates the interaction between myotubes and fibroblasts by IL-1Ra activity.  J Cell Mol Med. 2017-01. 
•  Tonsil-Derived Mesenchymal Stem Cells Differentiate into a Schwann Cell Phenotype and Promote Peripheral Nerve Regeneration.  Int J Mol Sci. 2016-11. 
•  Human tonsil‑derived mesenchymal stromal cells enhanced myelopoiesis in a mouse model of allogeneic bone marrow transplantation.  Mol Med Rep. 2016-10. 
•  Tonsil-Derived Mesenchymal Stem Cells Promote Bone Mineralization and Reduce Marrow and Visceral Adiposity in a Mouse Model of Senile Osteoporosis.  Stem Cells Dev. 2016-08. 
•  Improved Outcome of a Reduced Toxicity-Fludarabine, Cyclophosphamide, plus Antithymocyte Globulin Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia.  Biol Blood Marrow Transplant. 2016-08. 
•  Bioreducible-Cationic Poly(amido amine)s for Enhanced Gene Delivery and Osteogenic Differentiation of Tonsil-Derived Mesenchymal Stem Cells.  J Biomed Nanotechnol. 2016-05. 
•  Myogenic differentiation potential of human tonsil-derived mesenchymal stem cells and their potential for use to promote skeletal muscle regeneration.  Int J Mol Med. 2016-05. 
•  Differentiated tonsil-derived mesenchymal stem cells embedded in Matrigel restore parathyroid cell functions in rats with parathyroidectomy.  Biomaterials. 2015-10. 
•  Characterisation of insulin-producing cells differentiated from tonsil derived mesenchymal stem cells.  Differentiation. 2015-08. 
•  KMT2A (MLL)-MLLT1 rearrangement in blastic plasmacytoid dendritic cell neoplasm.  Cancer Genet. 2015-09. 
•  Tonsil-derived mesenchymal stromal cells produce CXCR2-binding chemokines and acquire follicular dendritic cell-like phenotypes under TLR3 stimulation.  Cytokine. 2015-06. 
•  Immune suppressive effects of tonsil-derived mesenchymal stem cells on mouse bone-marrow-derived dendritic cells.  Stem Cells Int. 2015-06. 
•  Tonsil-derived mesenchymal stem cells ameliorate CCl4-induced liver fibrosis in mice via autophagy activation.  Sci Rep. 2015-02. 
•  Clinical features, genetics, and outcome of pediatric patients with hemophagocytic lymphohistiocytosis in Korea.  Eur J Haematol. 2015-01. 
•  CCN1 secreted by tonsil-derived mesenchymal stem cells promotes endothelial cell angiogenesis via integrin αv β3 and AMPK.  J Cell Physiol. 2015-01. 
•  Characterization of long-term in vitro culture-related alterations of human tonsil-derived mesenchymal stem cells: role for CCN1 in replicative senescence-associated increase in osteogenic differentiation.  J Anat. 2014-11. 
•  3D culture of tonsil-derived mesenchymal stem cells in poly(ethylene glycol)-poly(L-alanine-co-L-phenyl alanine) thermogel.  Adv Healthc Mater. 2014-11. 
•  Differentiation of tonsil-tissue-derived mesenchymal stem cells controlled by surface-functionalized microspheres in PEG-polypeptide thermogels.  Biomacromolecules. 2014-06. 
•  Clinical features and treatment outcomes of Langerhans cell histiocytosis.  J Pediatr Hematol Oncol. 2014-03. 
•  Autologous stem cell transplantation for expansion of remnant liver volume with extensive hepatectomy. Hepatogastroenterology.  Hepatogastroenterology. 2014-02. 
•  Mesenchymal stem cells restore CCl4-induced liver injury by an antioxidative process.  Cell Biol Int. 2012-12. 
•  Macrophage inflammatory protein-2 (MIP-2)/CXCR2 blockade attenuates acute graft-versus-host disease while preserving graft-versus-leukemia activity.  Biochem Biophys Res Commun. 2012-10. 
•  Tonsil-derived mesenchymal stromal cells: evaluation of biologic, immunologic and genetic factors for successful banking.  Cytotherapy. 2012-11. 
•  Improved viability and activity of neutrophils differentiated from HL-60 cells by co-culture with adipose tissue-derived mesenchymal stem cells.  Biochem Biophys Res Commun. 2012-06. 
•  Tonsil-derived mesenchymal progenitor cells acquire a follicular dendritic cell phenotype under cytokine stimulation. Cytokine.  Cytokine. 2012-08. 
•  Erdheim-Chester disease with multisystem involvement in a 4-year-old.  Pediatr Radiol. 2012-05. 
•  Transplantation of bone marrow cells reduces CCl4 -induced liver fibrosis in mice.  Liver Int. 2011-08. 
•  Antitumor effects of imatinib mesylate and synergistic cytotoxicity with an arsenic compound in neuroblastoma cell lines.  Exp Ther Med. 2011-05. 
•  Clinical characteristics of hemophagocytic lymphohistiocytosis related to Kawasaki disease.  Pediatr Hematol Oncol. 2011-04. 
•  Epidemiology and clinical long-term outcome of childhood aplastic anemia in Korea for 15 years.  J Pediatr Hematol Oncol. 2011-04. 
•  Current status of pediatric umbilical cord blood transplantation in Korea: a multicenter retrospective analysis of 236 cases.  Am J Hematol. 2011-01. 
•  Bioimaging for the monitoring of the in vivo distribution of infused mesenchymal stem cells in a mouse model of the graft-versus-host reaction. .  Cell Biol Int. 2011-04. 
•  Osteoclast activation by receptor activator of NF-kappaB ligand enhances the mobilization of hematopoietic progenitor cells from the bone marrow in acute injury.  Int J Mol Med. 2010-10. 
•  Effect of retinoic acid on renal development in newborn mice treated with an angiogenesis inhibitor.  Pediatr Int. 2010-06. 
•  Mesenchymal stromal cells inhibit graft-versus-host disease of mice in a dose-dependent manner.  Cytotherapy. 2010-05. 
•  Hypoxia affected SDF-1alpha-CXCR4 interaction between bone marrow stem cells and osteoblasts via osteoclast modulation.  Acta Haematol. 2010-05. 
•  Mesenchymal stem cells showed the highest potential for the regeneration of injured liver tissue compared with other subpopulations of the bone marrow.  Cell Biol Int. 2009-07. 
•  Liver stem cells derived from the bone marrow and umbilical cord blood. .  Int J Stem Cells. 2009-05. 
•  Gene expression profile of mesenchymal stromal cells after co-culturing with injured liver tissue.  Mol Med Rep. 2009-02. 
•  Effect of hypoxic treatment on bone marrow cells that are able to migrate to the injured liver.  Cell Biol Int. 2009-01. 
•  In vitro hepatic differentiation of human umbilical cord blood and bone marrow cells.  Pediatr Hematol Oncol. 2008-09. 
•  Effect on cell cycle progression by N-Myc knockdown in SK-N-BE(2) neuroblastoma cell line and cytotoxicity with STI-571 compound.  Cancer Res Treat. 2008-03. 
•  Human eosinophils show chemotaxis to lymphoid chemokines and exhibit antigen-presenting-cell-like properties upon stimulation with IFN-gamma, IL-3 and GM-CSF.  Int Arch Allergy Immunol. 2008-03. 
•  Erythropoietin-independent and -dependent stages during in vitro erythropoiesis.  Acta Haematol. 2007-12. 
•  Pim-1 induced polyploidy but did not affect megakaryocytic differentiation of K562 cells and CD34+ cells from cord blood.  Eur J Haematol. 2007-02. 
•  Syngenic bone marrow cells restore hepatic function in carbon tetrachloride-induced mouse liver injury.  Stem Cells Dev. 2006-10. 
•  Arsenic trioxide concentration determines the fate of Ewing's sarcoma family tumors and neuroblastoma cells in vitro.  FEBS Lett. 2006-09. 
•  Iron removal with phlebotomy and recombinant human erythropoietin in secondary hemochromatosis after allogeneic bone marrow transplantation.  Pediatr Int. 2006-04. 
•  Morphological and biochemical changes induced by arsenic trioxide in neuroblastoma cell lines.  Pediatr Hematol Oncol. 2006-04. 
•  Arsenic trioxide inhibits cell growth in SH-SY5Y and SK-N-AS neuroblastoma cell lines by a different mechanism.  Pediatr Hematol Oncol. 2005-10. 
•  In vitro generation of functional dendritic cells from human umbilical cord blood CD34+ cells by a 2-step culture method.  Int J Hematol. 2004-10. 
•  Comparison of efficiency of ex vivo expansion of whole blood, mononuclear cells and purified CD34+ cells from human umbilical cord blood.  Haematologica. 2004-05. 
•  Ultrastructural and phenotypic analysis of in vitro erythropoiesis from human cord blood CD34+ cells.  Ann Hematol. 2003-10. 
•  Induction of the differentiation of HL-60 promyelocytic leukemia cells by L-ascorbic acid.  Free Radic Res. 2003-07. 
•  Autologous stem cell transplantation for the treatment of neuroblastoma in Korea.  J Korean Med Sci. 2003-04. 
•  Myeloablative treatment supported by autologous stem cell infusion with neuroblastoma.  J Korean Med Sci. 2003-04. 
•  In vitro differentiation of natural killer T cells from human cord blood CD34+ cells.  Br J Haematol. 2003-04. 
•  Functional maturation of myeloid cells during in vitro differentiation from human cord blood CD34+ cells.  Haematologica. 2002-11. 
•  Megakaryothrombopoiesis during ex vivo expansion of human cord blood CD34+ cells using thrombopoietin.  Scand J Immunol. 2002-11. 
•  Decrease in apoptosis and increase in polyploidization of megakaryocytes by stem cell factor during ex vivo expansion of human cord blood CD34+ cells using thrombopoietin.  Stem Cells. 2002-10. 
•  Apoptosis and megakaryocytic differentiation during ex vivo expansion of human cord blood CD34+ cells using thrombopoietin.  Br J Haematol. 2001-11. 
•  Cell cycling status of human cord blood CD34+ cells during ex vivo expansion is related to the level of very late antigen expression.  J Korean Med Sci. 2001-10. 
•  Stepwise multimodal approach in the treatment of Kasabach-Merritt syndrome.  Pediatr Int. 2000-10. 
•  Myeloid differentiation of human cord blood CD34+ cells during ex vivo expansion using thrombopoietin, flt3-ligand and/or granulocyte-colony stimulating factor.  Br J Haematol. 1999-10. 
•  Distinct patterns of apoptosis in association with modulation of CD44 induced by thrombopoietin and granulocyte-colony stimulating factor during ex vivo expansion of human cord blood CD34+ cells.  Br J Haematol. 1999-05. 

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